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Maitake alleviates intestinal inflammation


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Mush Zombie

Grifola frondosa mushroom water extract alleviates intestinal inflammation by suppressing TNF-α production and its signaling

TNF-α is a major cytokine involved in inflammatory bowel disease (IBD). In this study, water extract of Grifola frondosa (GFW) was evaluated for its protective effects against colon inflammation through the modulation of TNF-α action. In coculture of HT-29 human colon cancer cells with U937 human monocytic cells, TNF-α-induced monocyte adhesion to HT-29 cells was significantly suppressed by GFW (10, 50, 100 µg/ml). The reduced adhesion by GFW correlated with the suppressed expression of MCP-1 and IL-8, the major IBD-associated chemokines. In addition, treatment with GFW significantly suppressed TNF-α-induced reactive oxygen species production and NF-κB transcriptional activity in HT-29 cells. In differentiated U937 monocytic cells, LPS-induced TNF-α production, which is known to be mediated through NF-κB activation, was significantly suppressed by GFW. In an in vivo rat model of IBD, oral administration of GFW for 5 days (1 g/kg per day) significantly inhibited the trinitrobenzene sulfonic acid (TNBS)-induced weight loss, colon ulceration, myeloperoxidase activity, and TNF-α expression in the colon tissue. Moreover, the effect of GFW was similar to that of intra-peritoneal injection of 5-aminosalicylic acid (5-ASA), an active metabolite of sulfasalazine, commonly used drug for the treatment of IBD. The results suggest that GFW ameliorates colon inflammation by suppressing production of TNF-α as well as its signaling through NF-κB leading to the expression of inflammatory chemokines, MCP-1 and IL-8. Taken together, the results strongly suggest GFW is a valuable medicinal food for IBD treatment, and thus may be used as an alternative medicine for IBD.

Published by:

US National Library of Medicine

National Institutes of Health

Read the rest of the study here:

http://www.ncbi.nlm....31/?tool=pubmed

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KICKASS

Flawed I got some Maitaki spores if yah want some! lol! yah know.........your body craves things that it needs, if you ting (listen) closely. No wounder I love mushies! They make a body GOOD! Tanks MZ!

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  • 4 years later...
MConchis

Thanks for posting this.  This is just the stuff I'm looking for....gonna have to track some maitake down after I get to the point that I can grow ANY kind of mushroom.

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