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  1. Grifola frondosa mushroom water extract alleviates intestinal inflammation by suppressing TNF-α production and its signaling TNF-α is a major cytokine involved in inflammatory bowel disease (IBD). In this study, water extract of Grifola frondosa (GFW) was evaluated for its protective effects against colon inflammation through the modulation of TNF-α action. In coculture of HT-29 human colon cancer cells with U937 human monocytic cells, TNF-α-induced monocyte adhesion to HT-29 cells was significantly suppressed by GFW (10, 50, 100 µg/ml). The reduced adhesion by GFW correlated with the suppr
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